Postural Orthostatic Tachycardia Syndrome: Understanding the Science, Diagnosis, and Evidence-Based Management of POTS

Postural Orthostatic Tachycardia Syndrome (POTS) is one of the most recognized yet frequently misunderstood disorders of autonomic regulation. Although awareness has grown substantially in recent years, the condition continues to present significant diagnostic, physiological, and therapeutic challenges for clinicians and healthcare professionals.Postural Orthostatic Tachycardia Syndrome: Understanding the Science, Diagnosis, and Evidence-Based Management of POTS provides a comprehensive, clinically grounded examination of the disorder, integrating current knowledge of autonomic physiology, orthostatic adaptation, cardiovascular regulation, and contemporary management strategies.Beginning with the fundamental principles of autonomic nervous system function and circulatory control, this book explores the mechanisms that underlie orthostatic intolerance and the development of excessive postural tachycardia. Readers are guided through current diagnostic criteria, clinical assessment, autonomic testing, differential diagnosis, and the diverse manifestations of the condition.The text also examines important associated conditions, including connective tissue disorders, immune dysregulation, mast cell disorders, chronic fatigue syndromes, post-viral illness, and Long COVID, while maintaining a balanced and evidence-based perspective on evolving areas of research.Coverage includes:• Autonomic nervous system physiology and cardiovascular regulation• Orthostatic adaptation and circulatory control mechanisms• Current diagnostic criteria and clinical evaluation• Diagnostic testing and interpretation of findings• Differential diagnosis and overlapping conditions• Connective tissue, immune, and post-viral associations• Evidence-based nonpharmacological management strategies• Exercise rehabilitation and functional recovery principles• Pharmacologic treatment approaches and clinical decision-making• Long-term management, quality of life, and multidisciplinary care• Emerging research, precision medicine, and future directions in autonomic medicineWritten in a clear, professional, and clinically focused style, this volume is designed for physicians, nurse practitioners, physician assistants, medical trainees, allied health professionals, researchers, and healthcare providers seeking a deeper understanding of POTS and its place within modern autonomic medicine.Combining physiological foundations with practical clinical application, this book offers an authoritative resource for understanding one of the most complex and rapidly evolving disorders of autonomic function. Read more