- Justin Roiland as Mr. Poopybutthole, Cromulon, Eyeholes Man
- Sarah Chalke as Beth Smith, Plushy Beth, Xenobeth, Goddess Beth
- Spencer Grammer as Summer Smith
- Tara Strong as Tinkles, Doctor
- Keith David as The President, Reverse Giraffe
- Tricia Helfer as Donna Gueterman, Federation Robot
- Tress MacNeille as Caretaker, Roy's Mother
- Kurtwood Smith as General Nathan
- Gary Cole as Alien Doctor
- Alan Tudyk as Chris
- Kevin Michael Richardson as Mrs. Refrigerator, Frankenstein, Hamurai
- Cassie Steele as Tammy Gueterman
- John Kassir as Blim Blam
- Gary Anthony Williams as Assilimated Alien #4, Business Alien
- Chelsea Kane as Arthricia
- Scott Chernoff as Gear Head
- Brandon Johnson as Mr. Goldenfold
- Chris Parnell as Jerry Smith, Other Jerry, Another Jerry, Worm Jerry, Shaved Head Jerry, Tank Top-Wearing Jerry, Goatee Jerry, Heroic Jerry
- Ryan Ridley as Cousin Nicky, Head Vampire, Lighthouse Keeper, Roy's Doctor, Tax Attorney
- Tom Kenny as Pencilvester, Alien Inmate, Gear Newscaster, Gear Police Officer, Hunter, TSA Gromflamite, Wedding Bartender
- Maurice LaMarche as Miniverse President, Military Adviser, Military General, NASA Director, Rabbi
- Kari Wahlgren as Roy's Wife, Jessica
- Jess Harnell as Simon
- RICK AND MORTY SEASON 2 CHECKLIST
| Card | Where | Released |
| P1 | New York Comic-Con |
October 4-7, 2018 |
| P2 | Philly Non-Sports Card Show | October 20-21, 2018 |
| P3 | Box Break Promotion at Philly Non-Sports Card Show | October 20-21, 2018 |
| P4 | Non-Sport Update Magazine |
OCT/NOV 2018 |
| P5 |
Non-Sport Update Magazine |
OCT/NOV 2018 |
| P6 |
Non-Sport Update Magazine |
OCT/NOV 2018 |
| P7 | GTS National Hobby Shop Day |
December 8, 2018 |
| P8 | Emerald City Comic Con |
March 14-17, 2019 |